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20May

[Comment] A new step towards targeting tau

Progressive supranuclear palsy is a rare neurodegenerative disease characterised by an axial parkins...

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20May

[Review] CSF and blood biomarkers for Parkinson’s disease

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urg...

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22Apr

Parkinson’s disease patient: ‘I can walk… it’s really helped me’

Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fit...

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22Apr

Parkinson’s results beyond researchers’ wildest dreams

Previously housebound patients are now able to walk more freely as a result of electrical stimulatio...

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22Apr

Housebound Parkinson’s patients have movement restored

An electrical stimulus can help revive mobility for people with the disease, scientists have discove...

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11Apr

Direct beginnen met levodopa bij ziekte van Parkinson?*

Levodopa is het meest effectieve medicijn voor de behandeling van motorische symptomen bij patiënte...

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10Apr

‘I’m 35, with two young children – and Parkinson’s’

Ellie Finch Hulme is a translator and a busy mum of two children. And she also has a disease associa...

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20Mar

Parkinson’s smell test explained by science

A woman who can smell Parkinson's disease helps scientists discover what causes the musky odour...

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27Feb

Radical Parkinson’s treatment tested in patients

The drug is delivered to affected parts of the brain via a "port" in the side of the head....

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12Feb

[Review] Association between circadian rhythms and neurodegenerative diseases

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rh...

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12Feb

[Corrections] Correction to Lancet Neurol 2019; 18: 145–54

LeWitt PA, Hauser RA, Pahwa R, et al, on behalf of the SPAN-PD Study Investigators. Safety and effic...

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17Jan

[Articles] Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 trial

CVT-301 can improve UPDRS motor scores of patients with Parkinson's disease during in-clinic of...

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17Jan

[Comment] CVT-301 for Parkinson’s disease: dose and effect size issues

Oral levodopa plus a dopa-decarboxylase inhibitor (LD-DCI) is the standard of care for Parkinson...

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02Jan

Roken vermindert risico op ziekte van Parkinson

Rokers hebben een lager risico om de ziekte van Parkinson te krijgen dan niet-rokers. Dit is bevesti...

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14Dec

Zorgdeclaraties, een waardevolle bron van informatie

Vanwege de gevarieerde problematiek is voor mensen met de ziekte van Parkinson een multidisciplinair...

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13Dec

[In Context] Being Andrew Lees

The idea of interviewing Andrew Lees, Professor of Neurology at University College London and the Na...

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13Dec

[2018 Round-up] Movement disorders in 2018: tackling this evil at the roots

In 2018, several initiatives that have aimed to slow progression or prevent development of movement ...

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13Nov

[Correspondence] LRP10 in α-synucleinopathies

We read with interest the Article by Marialuisa Quadri and colleagues1 in The Lancet Neurology, in w...

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31Oct

Parkinson’s disease ‘may’ start in gut

The brain disease may actually start in the depths of the digestive system, US scientists say.Read m...

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16Oct

[Comment] The burden of Parkinson’s disease: a worldwide perspective

Over history, diseases have appeared and disappeared, or have increased or decreased in frequency. T...

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16Oct

[Articles] Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Over the past generation, the global burden of Parkinson's disease has more than doubled as a r...

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18Sep

[Review] Neuromodulation in the restoration of function after spinal cord injury

Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as...

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17Sep

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatr...

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14Aug

[Comment] At last, a randomised controlled trial of apomorphine infusion

For most medications, positive findings from large randomised controlled trials herald regulatory ap...

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14Aug

[In Context] The dark history of early deep brain stimulation

The development of modern deep brain stimulation (DBS) is widely attributed to Alim Benabid, who dis...

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14Aug

[Articles] Apomorphine subcutaneous infusion in patients with Parkinson’s disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial

Apomorphine infusion results in a clinically meaningful reduction in off time in patients with Parki...

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15Jun

[Review] Network imaging biomarkers: insights and clinical applications in Parkinson’s disease

Parkinson's disease presents several practical challenges: it can be difficult to distinguish f...

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15Jun

[Editorial] Difficult choices in treating Parkinson’s disease psychosis

Around half of all patients with advanced Parkinson's disease will develop hallucinations or de...

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15Jun

[Comment] A novel link between trafficking and Lewy body disorders

Elucidating the natural history and underlying genetic causes of Parkinson's disease and relate...

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15Jun

[Comment] Dissecting premotor Parkinson’s disease with multimodality neuroimaging

Parkinson's disease is diagnosed when parkinsonism (ie, bradykinesia, rigidity, and resting tre...

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15Jun

[In Context] Kapil Sethi: all about water buffaloes and refusing to be boring

You may know him as Professor Emeritus of Neurology at the Medical College of Georgia, Augusta Unive...

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15Jun

[In Context] Per Borghammer

Per Borghammer is a chief consultant and Associate Professor at the Department of Nuclear Medicine &...

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15Jun

[Articles] LRP10 genetic variants in familial Parkinson’s disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

Our findings implicate LRP10 gene defects in the development of inherited forms of α-synucleinopath...

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15Jun

[Articles] In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

Patients with idiopathic REM sleep behaviour disorder had fully developed pathology in the periphera...

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16May

[Review] Risk factors for non-motor symptoms in Parkinson’s disease

Non-motor symptoms (NMS) of Parkinson's disease can be predominant as the disease advances, the...

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16May

[In Context] The true face of James Parkinson

To celebrate the 200th anniversary of James Parkinson's Essay of the Shaking Palsy, there have ...

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16May

[In Context] Remembering the man behind An Essay on the Shaking Palsy

On Nov 16, 2017, a committed group of James Parkinson aficionados met for a historical walk at the A...

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25Apr

Dementia risk linked to some medicines

Up to two million people in England take anticholinergics, for depression and Parkinson's disea...

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13Mar

[In Context] Expecting exoskeletons for more than spinal cord injury

Exoskeletons that can help the paralysed to walk are available now. But they might also help patient...

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13Mar

[Articles] The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson’s disease: a cross-sectional PET study

LRRK2 mutations are associated with significantly increased cholinergic activity in the brain in mut...

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13Mar

[Correspondence] MPTP-induced parkinsonism: an historical case series

In 1982, seven young adults developed severe and irreversible parkinsonism shortly after they inject...

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13Mar

[Comment] Hypercholinergic activity in LRRK2 Parkinson’s disease

Mutations of the LRRK2 gene are a common cause of autosomal-dominant Parkinson's disease. The c...

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13Mar

[Editorial] Accelerating research for Parkinson’s disease

Despite considerable ongoing translational and clinical research efforts, no disease-modifying drugs...

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15Feb

Laserschoenen helpen patiënt met Parkinson lopen

Schoenen die zijn uitgerust met een klein laserapparaat dat een visuele stimulus geeft, zorgen ervoo...

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14Feb

‘I have Parkinson’s at 39 but it’s no reason to panic’

Marathon runner Aaron found he had Parkinson's aged 39 but through his love of exercise he'...

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13Feb

[Comment] Pimavanserin for patients with Alzheimer’s disease psychosis

Pimavanserin is an atypical antipsychotic marketed in the USA for hallucinations and delusions assoc...

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13Feb

[Comment] DBS for Parkinson’s disease with behavioural disturbances

Behavioural problems—eg, impulse control disorders, excessive and uncontrollable intake of levodop...

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13Feb

[Articles] Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson’s disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial

In a large cohort with Parkinson's disease and early motor complications, better overall behavi...

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12Feb

Parkinson’s sufferer ejected from Halfords ‘for funny walk’

Chris Cartlidge says he was told to leave Halfords after his symptoms caused his leg to stiffen.Read...

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12Feb

4e editie Sail4Parkinson!

De zeiltocht is opgezet om fondsen te werven voor onderzoek naar nieuwe behandelingen voor de ziekte...

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17Jan

[Articles] Effectiveness and costs of specialised physiotherapy given via ParkinsonNet: a retrospective analysis of medical claims data

These results confirm the findings from controlled trials, and offer evidence that specialised physi...

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17Jan

[Comment] Parkinson’s disease physiotherapy: specialisation adds value

In an era of evidence-based medicine, the value of rehabilitative therapies in Parkinson's dise...

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20Dec

Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson’s disease

Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's diseaseAuthor Co...

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18Dec

Bristol grandmother writing to beat Parkinson’s stigma

When Dawn May was diagnosed with the disease she wanted to teach her new grandson about it....

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18Dec

Scientists sniff out Parkinson’s disease smell

The breakthrough, inspired by Joy Milne's sense of smell, could lead to the first diagnostic te...

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18Dec

The woman who can smell Parkinson’s disease

Joy Milne has an amazing sense of smell that is bringing amazing results for scientists studying Par...

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15Dec

[2017 Round-up] High priority publications on Parkinson’s disease in 2017

Understanding how dopaminergic neurons die in Parkinson's disease is crucial to identify which ...

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15Dec

[Comment] Subthalamotomy for Parkinson’s disease: back to the future?

MRI-guided focused ultrasound is a novel method for creating thermic ablations in the thalamus or ba...

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15Dec

[Comment] The genetic architecture of dementia with Lewy bodies is shaping up

Genome-wide association studies (GWAS) have made substantial contributions to our understanding of c...

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15Dec

[In Context] Raul Martínez

Raul Martínez is a neurologist and clinical researcher at Centro Integral en Neurociencias (CINAC),...

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