13Mar

[Comment] Hypercholinergic activity in LRRK2 Parkinson’s disease

Mutations of the LRRK2 gene are a common cause of autosomal-dominant Parkinson's disease. The clinical features of manifest LRRK2 Parkinson's disease are generally indistinguishable from those of sporadic Parkinson's disease, although some features might be less prominent, including diminished hyposmia and less cognitive decline.1 Study of premanifest LRRK2 Parkinson's disease has the potential to identify early and important events in Parkinson's disease pathophysiology and pathogenesis. Cholinergic system changes are implicated in several non-motor features of idiopathic Parkinson's disease.

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20May

[Comment] A new step towards targeting tau

Progressive supranuclear palsy is a rare neurodegenerative disease characterised by an axial parkins...

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20May

[Review] CSF and blood biomarkers for Parkinson’s disease

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urg...

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22Apr

Parkinson’s disease patient: ‘I can walk… it’s really helped me’

Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fit...

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