Parkinson Platform Noord Nederland

Parkinson's disease is diagnosed when parkinsonism (ie, bradykinesia, rigidity, and resting tremor) is clinically apparent. Parkinsonism manifests when a dopaminergic deficit of about 80% is present in the striatum due to neuronal loss of about 60% in the substantia nigra pars compacta. Parkinson's disease has a premotor period of several years during which progressive neuronal loss occurs outside the substantia nigra in non-dopaminergic regions, leading to non-motor symptoms such as hyposmia, constipation, depression, and rapid eye movement (REM) sleep behaviour disorder.