Parkinson Platform Noord Nederland

Over the past two decades, more than 25 mutant genes have been associated with familial forms of parkinsonism, including the gene encoding leucine-rich repeat kinase 2 (LRRK2).1 Dominantly inherited mutations in LRRK2 are associated with the highest attributable risk in populations with familial and sporadic forms of Parkinson's disease.2 In The Lancet Neurology, Daryl Wile and colleagues3 report results from a dopaminergic and serotonergic PET imaging study in LRRK2 mutation carriers with and without manifest Parkinson's disease, who they assessed in parallel with a cohort of individuals with sporadic Parkinson's disease and healthy controls.