[In Context] Parkinson’s disease and thalamus: facts and fancy
The hallmark feature of Parkinson's disease is the degeneration of dopaminergic neurons in the ventrolateral region of the substantia nigra pars compacta, accompanied by dopamine striatal deficit and accumulation of aggregated α-synuclein (known as Lewy bodies) in the remaining neurons, as well as in other brainstem nuclei, amygdala, and cortical regions. Dopamine deficiency leads to a cascade of functional changes in neuronal activity in basal ganglia circuits, which are ultimately responsible for the cardinal features of Parkinson's disease.
Ander nieuws
[Comment] A new step towards targeting tau
Progressive supranuclear palsy is a rare neurodegenerative disease characterised by an axial parkins...
[Review] CSF and blood biomarkers for Parkinson’s disease
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urg...
Parkinson’s disease patient: ‘I can walk… it’s really helped me’
Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fit...