11Apr

[Comment] Disease progression in LRRK2 parkinsonism

Over the past two decades, more than 25 mutant genes have been associated with familial forms of parkinsonism, including the gene encoding leucine-rich repeat kinase 2 (LRRK2).1 Dominantly inherited mutations in LRRK2 are associated with the highest attributable risk in populations with familial and sporadic forms of Parkinson's disease.2 In The Lancet Neurology, Daryl Wile and colleagues3 report results from a dopaminergic and serotonergic PET imaging study in LRRK2 mutation carriers with and without manifest Parkinson's disease, who they assessed in parallel with a cohort of individuals with sporadic Parkinson's disease and healthy controls.

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20May

[Comment] A new step towards targeting tau

Progressive supranuclear palsy is a rare neurodegenerative disease characterised by an axial parkins...

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20May

[Review] CSF and blood biomarkers for Parkinson’s disease

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urg...

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22Apr

Parkinson’s disease patient: ‘I can walk… it’s really helped me’

Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fit...

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