Parkinson Platform Noord Nederland

In a large clinicopathological correlative study in The Lancet Neurology, David J Irwin and colleagues1 investigate Alzheimer's disease pathology (ie, amyloid-β neuritic plaques and tau neurofibrillary tangles), α-synuclein Lewy body pathology, and other concomitant pathologies post-mortem in the brains of patients with clinically diagnosed synucleinopathies, which encompass dementia with Lewy bodies and Parkinson's disease dementia. Irwin and colleagues report that increased severity of Lewy body pathology and Alzheimer's disease pathology were associated with a shorter interval between onset of motor symptoms and onset of dementia and shorter disease duration.