13Nov

[Correspondence] LRP10 in α-synucleinopathies

We read with interest the Article by Marialuisa Quadri and colleagues1 in The Lancet Neurology, in which they suggested LRP10 mutations as a cause of Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. As part of the International Parkinson's Disease Genomics Consortium, we analysed LRP10 in exome sequencing data from 2835 individuals with Parksinson's disease and 5343 individuals without known neurological disease (appendix). We also analysed exome sequencing data from 111 individuals with pathologically confirmed dementia with Lewy bodies and another 233 individuals without known neurological disease (appendix).

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20May

[Review] CSF and blood biomarkers for Parkinson’s disease

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urg...

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20May

[Comment] A new step towards targeting tau

Progressive supranuclear palsy is a rare neurodegenerative disease characterised by an axial parkins...

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22Apr

Parkinson’s disease patient: ‘I can walk… it’s really helped me’

Parkinson's disease patient Gail Jardine can walk more freely after having a spinal implant fit...

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